Synaptica develops computational neuroscience tools for epilepsy predictions. Ion channel dynamics and biologically realistic spiking neural networks can provide insights into how alterations in the molecular machinery relate to channelopathies such as epilepsy.

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Synaptica uses NEURON Simulator with NetPyNE:

We simulate ion channel structures and dynamics using protein folding software (AlphaFold2) and derive features to predict the functional consequence of ion channel mutations.