Through the EuroCC Open Call Application, Synaptica was awarded access to Snellius, the largest supercomputer in the Netherlands, in order to perform protein folding simulations of mutated ion channels. These simulations will be used to predict the functional consequences of ion channel mutations related to channelopathies such as epilepsy.


Synaptica obtained the 2-year R&D MIT AI research grant together with SME Artinis Medical Systems (Elst, Netherlands). Synaptica will advance a method that simulates neuron activity for humans using a computer model of biologically realistic spiking neurons and neural networks. Artinis Medical Systems, world leading expert on fNIRS headsets to measure brain activity in real time, will in the project develop an epilepsy headset to detect seizure activity. Together, these novel tools aim to increase the accuracy of diagnosis and treatment of epilepsy.

Founding information

Synaptica B.V. is a medical-scientific research and development company. Synaptica performs epilepsy calculations using biologically realistic spiking brain circuit models.

Synaptica is founded by Dr. Marijn Martens; Marijn graduated cum laude in 2010 with a Master’s degree in Cognitive Neuroscience from the Donders Graduate School for Cognitive Neuroscience. That year he obtained a TOPTalent NWO grant and used it to conduct his PhD research titled Emerging Brain Circuits within the Department of Neuroinformatics at the Donders Institute in Nijmegen. After his PhD in 2015, Marijn worked at startups where he focused on offering medical specialists tools for personalized diagnosis, prognosis and ultimately treatment based on (digital) biomarkers.

List of publications

  • 2023 Human cortical spheroids with a high diversity of innately developing brain cell types, Kim de Klein, (..), M.B. Martens et al., Stem Cell Research & Therapy
  • 2021 Two-Minute Walking Test With a Smartphone App for Persons With Multiple Sclerosis: Validation Study, Pim van Oirschot, (..), M.B. Martens et al., JMIR Formative Research
  • 2020 Key role for lipids in cognitive symptoms of Schizophrenia, Dorien Maas, (..), M.B. Martens et al, Translational Psychiatry
  • 2020 Symbol Digit Modalities Test variant in a smartphone app for persons with multiple sclerosis: validation study, Pim van Oirschot, (..), M.B. Martens et al, JMIR Mhealth
  • 2020 Shared genetic etiology between Parkinson’s disease and blood levels of specific lipids, Helena Xicoy, (..), M.B. Martens et al, NPJ Parkinson’s Disease
  • 2019 Toward Digital Self-monitoring of Multiple Sclerosis: Investigating First Experiences, Needs, and Wishes of People with MS, Karine Wendrich, (..), M.B. Martens et al.,
  • 2019 Sensitivity to Stimulus Irregularity Is Inherent in Neural Networks, van Gils, Tiesinga, M.B. Martens, Neural Computation
  • 2017 Integrated molecular landscape of Parkinson’s disease, Koen klemann, (..), M.B. Martens et al., NPJ Parkinson’s Disease
  • 2017 Autism spectrum disorders and autistic traits share genetics and biology, Janita Bralten, (..), M.B. Martens et al, J Mol Psychiatry
  • 2017 Anti-correlations in the degree distribution increase stimulus detection performance in noisy spiking neural networks. Marijn Martens et al, J Comput Neurosci.
  • 2016 Euchromatin histone methyltransferase 1 regulates cortical neuronal network development, Martens MB et al. Scientific Reports
  • 2015 A Developmental Switch for Hebbian Plasticity, Marijn Martens, Tansu Celikel, Paul Tiesinga, PLoS Comput Biology
  • 2014 Separating burst from background spikes in multichannel neuronal recordings using return map analysis. Martens MB et al, Int J Neural Syst
  • 2010 Applying double-magnetic induction to measure head-unrestrained gaze shifts: calibration and validation in monkey. Peter Bremen, (..), M.B. Martens et al, Biol Cybern.